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The same laboratory where Emil Hansen isolated yeast to a single strain, something we take for granted today. Prior to that multiple strains were pitched and replication of a beer from batch to batch was sketchy at best.The Dane that came up with the concept did so while working at Carlsberg Laboratories....yes that Carlsberg.
Beer has improve a great deal in the last +130 years. I don't believe the beer was nearly as good 150 years ago as it is today, thanks to technical advances.